Tuesday, November 30, 2021

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HLA Typing Antibody Detection


Antibody Detection

One Lambda’s Antibody Detection products have been designed to monitor transplant patients, both pre- and post-transplant. They are used to detect HLA antibodies that may cause graft rejection. With five different product lines, One Lambda allows laboratories to choose a solution that best suits their needs.

  • Our FlowPRA® products provide HLA PRA screening and antibody specificity assignment by flow cytometry.
  • The Lambda Antigen Tray™ features ELISA-based assays for detection of HLA IgG antibody.
  • LABScreen® PRA identifies and detects PRA and HLA specificities by LABScan™ 100 flow analyzer.
  • Our Lambda Cell Trays™ detect PRA by microcytotoxicity.
  • iBeads™ investigates antibodies to native conformation HLA antigens.*
  iBeads™ investigates antibodies to native conformation HLA Class I antigens. Using a panel of color coded microbeads, that have a reduced amount of denatured antigens, researchers can investigate antibody reactivity in unsensitized individuals.FlowPRAThe FlowPRA® product line offers screening and specific antibody detection assays using flow cytometry. Both the FlowPRA® Screening and Specific tests can assign Percent Panel Reactive Antibody (PRA), while FlowPRA® Specific tests assign antibody specificity. FlowPRA® Single Antigen tests assist in the analysis of specificities, especially in high PRA sera.


  FlowPRA® Screening  
    FlowPRA® Specific
    FlowPRA® Single Antigen
    FlowPRA® Control Beads
    FlowPRA® Serum Controls
    Ancillary Products

The LABScreen® product line, consisting of LABScreen® PRA, LABScreen® Mixed, and LABScreen® Single Antigen, uses a panel of color-coded microspheres coated with HLA antigens to determine percent PRA and to identify antibody specificities. The LABScreen® line is part of the Lambda Array Beads Multi-Analyte System (LABMAS), utilizing the LABScan™ 100 flow analyzer for data acquisition and analysis.


  LABScreen® PRA
    LABScreen® Mixed
    LABScreen® Multi
    LABScreen® Single Antigen
    LABScreen® Singles
    Ancillary Products
    Ancillary Products (Controls)

Lambda Antigen Trays™ (LAT)

Lambda Antigen Trays are economical and convenient ELISA-based assays for the detection of HLA IgG antibody. The product line includes an LAT™ Mixed assay, which may be used as a pre-screening test. In addition, the LAT™ features pools of HLA antigens, which allow the determination of percent PRA and the identification of specific HLA Class I and Class II antibodies on a single tray.

    LAT™ Mixed
    LAT™ Single Antigen

Lambda Cell Trays™ (LCT)

Lambda Cell Trays™ (LCT) are frozen cell panels designed for Panel Reactive Antibody (PRA) and HLA antibody screening by complement-dependent cytotoxicity. The LCT™ provides a diverse cell panel for cytotoxic screening of human sera.Lambda Cell Trays™ consist of Class I panels with selected lymphocytes frozen onto Terasaki Trays, each carefully constructed to assure maximum antigen coverage. Trays are available in both 60 and 72 well formats.
  Features & Benefits
  • Extensive antigen coverage
  • Multiple panel sizes (30, 60 & 72)
  • Combine Lambda Cell Trays for larger cell panels
  • One and one-half hour total test time
  • Accurate results
  • Excellent viability
  • Suited for dye exclusion and fluorescence methods